Mechanisms of Internalization of Staphylococcus aureus by Cultured Human Osteoblasts
نویسندگان
چکیده
منابع مشابه
Mechanisms of internalization of Staphylococcus aureus by cultured human osteoblasts.
Staphylococcus aureus is an important bone pathogen, and evidence shows that this organism is internalized by chick osteoblasts. Here we report that S. aureus is internalized by human osteoblasts. Internalization was inhibited by monodansylcadaverine and cytochalasin D and to a lesser extent by ouabain, monensin, colchicine, and nocodazole. We propose that internalization occurs via a receptor-...
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Individual strains of Staphylococcus aureus have different capacities to become internalized by osteoblasts. Here we report that the levels of sigma(B) expressed by S. aureus correlate with the capacity of this bacterium to be internalized by osteoblasts. However, sigma(B) is not essential for internalization and does not necessarily account for the differences in the capacities of strains to b...
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Finding new strategies to counteract periprosthetic infection and implant failure is a main target in orthopedics. Staphylococcus aureus, the leading etiologic agent of orthopedic implant infections, is able to enter and kill osteoblasts, to stimulate pro-inflammatory chemokine secretion, to recruit osteoclasts, and to cause inflammatory osteolysis. Moreover, by entering eukaryotic cells, staph...
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Introduction: Since the incidence of various infections caused by Staphylococcus aureus increases, the use of effective antibiotics such as clindamycin has been growing to treat the systemic and local infections caused by such organisms. Antibiotic-resistant species are emerging and spreading in today's communities due to misuse of antibiotics and incomplete treatment, turning into a serious ch...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1999
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.67.5.2677-2681.1999